login
Password reminder
Cardiovascular News
Contact the editor Visit Cardiovascular News Twitter feed Visit Cardiovascular News Facebook page
 

Catheter-based ultrasound technology lower resistant hypertension, SOUND ITV study shows


Wednesday, 15 Aug 2012 11:36
Vivek Reddy
Vivek Reddy


On 14 August, Sound Interventions released three-month data from the company’s first-in-human clinical study (SOUND-ITV) to treat resistant hypertension through the use of catheter-based ultrasound.  


In addition to office-based blood pressure measurements, patients in the study underwent 24-hour ambulatory blood pressure monitoring prior to the ultrasonic renal denervation procedure, and subsequently three months after the procedure. The office-based blood pressure measurement results showed an average decrease of -25.6/-12.5 mm Hg. Consistent with these results the 24-hour mean blood pressure decreased by -23.1/-11.9 mm Hg.

Patients were treated at Holmolka Hospital in Prague, Czech Republic. Patients enrolled in the study were selected based on a history of hypertension which could not be controlled with medical therapy. The SOUND-ITV study was designed to evaluate the safety and effectiveness of the company’s volumetric dosimetry-controlled application of unfocused ultrasound (patents pending).


“These results demonstrate the ability of Sound Interventions’ ultrasound technology to significantly lower blood pressure in patients whose blood pressure was unable to be controlled by conventional pharmaceutical therapy,” said Petr Neuzil, chairman, Department of Cardiology of Holmolka Hospital.


Vivek Reddy, Mt Sinai Medical Center in New York City who collaborated with Neuzil and who is an advisor to Sound Interventions, commented: “The use of 24-hour monitoring to assess results of renal denervation procedures is a more accurate measurement of effectiveness than office-based blood pressure. The favorable results seen on the ambulatory blood pressure monitoring fortify our confidence in the efficacy of this technology.”


“These results, demonstrate the efficacy of Sound Interventions ultrasound dosimetry-controlled approach to renal denervation. Prior to initiation of the SOUND-ITV study, the company performed extensive in-vitro and in-vivo testing in order to perfect the ultrasound dosimetry. The pre-clinical testing has demonstrated that the Sound Interventions technology is unique in its ability to ablate the target nerve fibers while sparing the arterial wall,” said David Smith, president and CEO of Sound Interventions. “The success of the acute procedures in the SOUND-ITV study, along with these very strong clinical results validate this research and indicate that we are well on the way to developing the state-of-the-art renal denervation technology.”


Results of the SOUND-ITV study will be presented at the upcoming TCT 2012 Conference (Miami, USA, 22–26 October 2012).




Add New Comment

Related Items


Most popular


Bioresorbable scaffolds have the potential “to be workhorse stents”
Thursday, 07 May 2015
Last year, the GHOST-EU registry indicated that the rate of scaffold thrombosis with the bioresorbable vascular scaffold (Absorb, Abbott Vascular) was “not negilible”. However, as technological ... Bioresorbable scaffolds have the potential “to be workhorse stents”

Merit Medical Systems launches the Prelude Snap splittable sheath introducer
Wednesday, 03 Jun 2015
Merit Medical Systems has launched the Prelude Snap splittable sheath introducer, the design of which is based directly on physician feedback. Merit Medical Systems launches the Prelude Snap splittable sheath introducer

LowerMyDose website launches
Wednesday, 03 Jun 2015
LowerMyDose.com promotes peer-to-peer engagement through real-life experience sharing about the concerns of excessive and unnecessary radiation exposure. LowerMyDose website launches

Features


The importance of the PLATINUM DIVERSITY trial
Wednesday, 24 Jun 2015
The PLATINUM DIVERSITY trial was initiated last year with the aim of evaluating the clinical outcomes of an everolimus-eluting stent (Promus Premier, Boston Scientific) in patient populations that ... The importance of the PLATINUM DIVERSITY trial

The current status of transcatheter pulmonary valve replacement
Tuesday, 09 Jun 2015
The Melody transcatheter pulmonary valve (Medtronic), which received the CE mark in 2006 and FDA humanitarian device exemption approval in 2010, was recently granted FDA premarket approval. In this ... The current status of transcatheter pulmonary valve replacement

Profiles


Deepak L Bhatt
Tuesday, 09 Jun 2015
Deepak L Bhatt (Executive director of Interventional Cardiovascular Programs, Brigham and Women’s H... Deepak L Bhatt

Flavio Ribichini
Thursday, 05 Mar 2015
Flavio Ribichini speaks to Cardiovascular News about being involved in the first use of primary ... Flavio Ribichini

Cardiac Rhythm News Vascular News Cardiovascular News Interventional News Spinal News NeuroNews
BIBA Medical BIBA MedTech Insights CX Symposium ilegx
Password Reminder

BIBA Medical, 526 Fulham Road, Fulham, London, SW6 5NR.
TEL: +44 (0)20 7736 8788 FAX: +44 (0)20 7736 8283 EMAIL: 
info@bibamedical.com
© BIBA Medical Ltd is a company registered in England and Wales with company number 2944429.
VAT registration number 730 6811 50.
Site Map | Terms and Conditions