login
Password reminder
Cardiovascular News
Contact the editor Visit Cardiovascular News Twitter feed Visit Cardiovascular News Facebook page
 

Catheter-based ultrasound technology lower resistant hypertension, SOUND ITV study shows


Wednesday, 15 Aug 2012 11:36
Vivek Reddy
Vivek Reddy


On 14 August, Sound Interventions released three-month data from the company’s first-in-human clinical study (SOUND-ITV) to treat resistant hypertension through the use of catheter-based ultrasound.  


In addition to office-based blood pressure measurements, patients in the study underwent 24-hour ambulatory blood pressure monitoring prior to the ultrasonic renal denervation procedure, and subsequently three months after the procedure. The office-based blood pressure measurement results showed an average decrease of -25.6/-12.5 mm Hg. Consistent with these results the 24-hour mean blood pressure decreased by -23.1/-11.9 mm Hg.

Patients were treated at Holmolka Hospital in Prague, Czech Republic. Patients enrolled in the study were selected based on a history of hypertension which could not be controlled with medical therapy. The SOUND-ITV study was designed to evaluate the safety and effectiveness of the company’s volumetric dosimetry-controlled application of unfocused ultrasound (patents pending).


“These results demonstrate the ability of Sound Interventions’ ultrasound technology to significantly lower blood pressure in patients whose blood pressure was unable to be controlled by conventional pharmaceutical therapy,” said Petr Neuzil, chairman, Department of Cardiology of Holmolka Hospital.


Vivek Reddy, Mt Sinai Medical Center in New York City who collaborated with Neuzil and who is an advisor to Sound Interventions, commented: “The use of 24-hour monitoring to assess results of renal denervation procedures is a more accurate measurement of effectiveness than office-based blood pressure. The favorable results seen on the ambulatory blood pressure monitoring fortify our confidence in the efficacy of this technology.”


“These results, demonstrate the efficacy of Sound Interventions ultrasound dosimetry-controlled approach to renal denervation. Prior to initiation of the SOUND-ITV study, the company performed extensive in-vitro and in-vivo testing in order to perfect the ultrasound dosimetry. The pre-clinical testing has demonstrated that the Sound Interventions technology is unique in its ability to ablate the target nerve fibers while sparing the arterial wall,” said David Smith, president and CEO of Sound Interventions. “The success of the acute procedures in the SOUND-ITV study, along with these very strong clinical results validate this research and indicate that we are well on the way to developing the state-of-the-art renal denervation technology.”


Results of the SOUND-ITV study will be presented at the upcoming TCT 2012 Conference (Miami, USA, 22–26 October 2012).




Add New Comment

Related Items


Most popular


FDA proposes ban on most powdered medical gloves
Tuesday, 22 Mar 2016
The US Food and Drug Administration has announced a proposal to ban most powdered gloves in the USA. While use of these gloves is decreasing, they pose an unreasonable and substantial risk of illness ... FDA proposes ban on most powdered medical gloves

Abbott Vascular recalls MitraClip clip delivery system
Wednesday, 16 Mar 2016
Abbott Vascular has recalled the MitraClip clip delivery system, following reports of issues with the delivery system deployment process. Abbott Vascular recalls MitraClip clip delivery system

Thursday, 10 Mar 2016
Pil Hyung Lee and others report that successful PCI of a native chronic total occlusion lesion is not associated with improved long-term survival compared with a failed procedure. Successful PCI of chronic total occlusions does not improve long-term survival

Features


The role of sutureless and rapid-deployment valves
Tuesday, 05 Apr 2016
Antonio Miceli explores the data for sutureless and rapid-deployment surgical valves for the management of patients with severe aortic stenosis. He also reviews the place of these new devices ... The role of sutureless and rapid-deployment valves

The SCOUT study: Transcatheter tricuspid repair
Friday, 18 Mar 2016
Rebecca Hahn is the principal investigator of the SCOUT trial, which is evaluating the use of Mitralign’s transcatheter tricuspid repair system for the management of tricuspid regurgitation. She ... The SCOUT study: Transcatheter tricuspid repair

Profiles


Alexandra Lansky
Monday, 07 Mar 2016
Alexandra Lansky (Director, Heart and Vascular Clinical Research Program, Yale University School of ... Alexandra Lansky

Corrado Tamburino
Tuesday, 20 Oct 2015
Corrado Tamburino (full professor of Cardiology, Ferrarotto & Policlinico Hospitals, University of C... Corrado Tamburino

Cardiac Rhythm News Vascular News Cardiovascular News Interventional News Spinal News NeuroNews
BIBA Medical BIBA MedTech Insights CX Symposium ilegx
Password Reminder

BIBA Medical, 526 Fulham Road, Fulham, London, SW6 5NR.
TEL: +44 (0)20 7736 8788 FAX: +44 (0)20 7736 8283 EMAIL: 
info@bibamedical.com
© BIBA Medical Ltd is a company registered in England and Wales with company number 2944429.
VAT registration number 730 6811 50.
Site Map | Terms and Conditions