login
  Password reminder
Vascular News
Contact the editor Visit Vascular News Twitter feed Visit Vascular News Facebook page
 

US researchers identify “master coordinator” for aortic dissection


Tuesday, 25 Jun 2013 12:07
Allan Brasier
Allan Brasier

New findings from a study carried out by investigators from the University of Texas Medical Branch (UTMB) at Galveston, USA, have identified a lymphocyte that is responsible for the cellular inflammation of the aortic wall that causes aortic dissections.

In earlier studies, researchers from the UTMB at Galveston linked the blood-pressure-regulating molecule, angiotensin II, to the immune signalling protein IL6, which they determined played a major role in producing aortic dissections. Exactly how IL6 generated the inflammation leading to aortic dissection remained unknown, however.

Now the UTMB researchers have found what they believe is the missing piece of the puzzle in a group of cells called Th17 lymphocytes. Part of the body’s adaptive immune system, these cells normally serve a protective function; they generate a protein called IL17 to bring other cells to support immune defences. But in laboratory mouse experiments, the scientists found that locally produced vascular IL6 promotes Th17 formation and accumulation in the vessel wall. There, Th17 lymphocytes instigate a misguided immune attack on the aorta.

“In our study, we compared the effects of angiotensin II on normal mice and mice deficient in Th17 cells, either genetically or by blocking its action,” said UTMB professor Allan Brasier, senior author of a paper on the discovery now online in the journal Arteriosclerosis, Thrombosis, and Vascular Biology. “The results showed us that interfering with the Th17 lymphocyte significantly reduces dissections. These data suggest that Th17 lymphocyte is the master coordinator of cellular inflammation in the vessel wall.”

To establish the clinical relevance of their findings, the scientists examined tissue samples from patients with a genetic mutation that predisposed them to aortic dissections. The samples, which were derived from a bank maintained by University of Texas Health Science Center at Houston professor and paper author Dianna Milewicz, showed clear signs of Th17 cell accumulation.

“The idea here is that the immune system has evolved to protect us against viruses and bacteria, these sorts of things,” Brasier said. “But under certain pathological conditions, the immune system can actually produce disease through chronic inflammation.”

Other authors of the paper include graduate students Xiaoxi Ju and Talha Ijaz, research associates Hong Sun, Chang Lee and Wanda Lejeune, assistant professors Sutapa Ray and Adrian Recinos and professor Ronald Tilton, as well as UTHSC-Houston’s Dong-Chuan Guo.




Add New Comment

Most popular


ROADSTER trial studying new path to carotid revascularisation completes patient enrolment
Friday, 18 Jul 2014
The trial was the first of its kind to study the treatment of carotid artery stenosis by placing a stent via direct access to the common carotid artery in the neck in an entirely new minimally ... ROADSTER trial studying new path to carotid revascularisation completes patient enrolment

IMPROVE trial morphology analysis: The answer lies in the neck
Wednesday, 02 Jul 2014
An analysis of aneurysm morphology in the IMPROVE trial showed that for long aneurysm necks, mortality after endovascular aneurysm repair (EVAR) and open repair was very similar. Surprisingly, the ... IMPROVE trial morphology analysis: The answer lies in the neck

Endovascular-first strategy for aortoiliac lesions irrespectively of TASC category
Thursday, 17 Jul 2014
Two-year data from a prospective, multicentre study suggest that endovascular therapy with stenting may be considered the preferred first-line treatment option for aortoiliac lesions, irrespectively ... Endovascular-first strategy for aortoiliac lesions irrespectively of TASC category

Features


SPECT can predict cardiovascular mortality in elective aneurysm repair patients
Wednesday, 12 Mar 2014
Kimihiro Komori and Yosuke Inoue analyse the results of a study that concluded that preoperative pharmacologic stress myocardial perfusion SPECT is not only safe, but is also a useful method to ... SPECT can predict cardiovascular mortality in elective aneurysm repair patients

Hybrid techniques for the arch: are they effective and durable?
Monday, 17 Feb 2014
Piergiorgio Cao writes that despite the perioperative mortality risk, the late outcome of endovascular arch repair presents a low rate of aorta-related deaths and reinterventions and acceptable mid-... Hybrid techniques for the arch: are they effective and durable?

Profiles


Cliff Shearman
Thursday, 03 Jul 2014
A former president of the Vascular Society of Great Britain and Ireland, Cliff Shearman was ... Cliff Shearman

Andrew Holden
Tuesday, 11 Feb 2014
Andrew Holden has been involved in the investigation of several endovascular devices for the ... Andrew Holden

Cardiac Rhythm News Vascular News Cardiovascular News Interventional News Spinal News NeuroNews
BIBA Medical BIBA MedTech Insights CX Symposium ilegx
 
Password Reminder

BIBA Medical, 526 Fulham Road, Fulham, London, SW6 5NR.
TEL: +44 (0)20 7736 8788 FAX: +44 (0)20 7736 8283 EMAIL: 
info@bibamedical.com
© BIBA Medical Ltd is a company registered in England and Wales with company number 2944429.
VAT registration number 730 6811 50.
Site Map | Terms and Conditions